Dr. Montazeri’s research is focused on delivery systems and RNA interference via small interfering RNAs (siRNAs). Regarding delivery systems, recent efforts in Dr. Montazeri’s project have shown efficient silencing of specific proteins in different human breast cancer cell lines. Studies on developing new safe and efficient multicomponent lipid-based carriers generally known as stable nucleic acid lipid particles (SNALPs) are underway, which will be designed for active targeting of solid tumors. Protein silencing investigations in his lab are focused on understanding the interconnections among the signaling pathways involved in enhanced proliferation and survival, as well as, resistance to chemotherapeutic agents in cancer cells. Dr. Montazeri is specifically evaluating the potential of combinational silencing of selected proteins in an effort to effectively eradicate tumor growth.
