Dr. Rose's translational research interests involve the pharmacodynamic effects of antimicrobials on antibacterial resistance development and virulence expression. His laboratory incorporates multiple in vitro modeling systems to simulate antimicrobial exposures against multi-drug resistant pathogens. These studies are used to evaluate optimal antibiotic activity, antibiotic penetration into simulated infections, the development of antibiotic resistance, and virulence His clinical studies involve the impact of patient immune responses and bacterial virulence on the treatment outcome of invasive S. aureus infections.
