The general goal of research in my laboratory is to elucidate mechanisms of infectious diseases. In particular, we study bacterial antibiotic resistance conferred by metallo-beta-lactamases. The clinically most relevant of these enzymes are those of the IMP and VIM type, and more recently also NDM-1. We want to understand how these enzymes function and evolve under the selective pressure of antibiotics. In collaboration with other researchers in the field, we hope to discover more potent antibiotics and metallo-beta-lactamase inhibitors that can be given in combination with antibiotics. These could improve treatment while limiting the spread and evolution of metallo-beta-lactamases.
